Retrieved 14 November They are being tested for antisense gene regulation, which has been demonstrated both in vivo and in vitro. And no, the papers on nano-flares are not underpinning the clinical trials, the papers on gene regulation are. Retrieved January 31, Rathmann professor of chemistry, professor of medicine, professor of materials science and engineering , professor of biomedical engineering , and professor of chemical and biological engineering, and director of the International Institute for Nanotechnology and Center for Nanofabrication and Molecular Self-Assembly at Northwestern University.
Nanobiosystems, Medicine, and Health” and “Synthesis, Processing, and Manufacturing of Components, Devices, and Systems” to the world study on nanotechnology research directions for societal needs Nanotechnology Research Directions for Societal Needs in Yet, in spite of the massive amount of funding, the dozens of articles, the upcoming clinical trials, and the fact that the technology required to establish endosomal escape has been available for more than half of century and is, literally, routine, the data are lacking. Retrieved 14 November You are commenting using your Twitter account. Leave a Reply Cancel reply Enter your comment here
CoI statement from the paper: Given that we are talking about experiments on humans, I tthesis have thought that this is a pretty serious concern.
Calling the clinical trials for spherical nucleic acids into question is disingenuous. Chad Alexander Mirkin born November 23, is midkin American chemist. Therefore we would be in a position where dozens of papers on the basic technology underpinning the clinical trials are, at the very least, questionable.
The mechanism of action of a drug does not need to be elucidated for it to be approved by the FDA, it just needs to be safe and effective.
A follow up paper by mitkin same group is discussed here. I happen to agree with you that the flares lighting up in the endosome is a serious issue to be addressed phf most certainly interferes with accurate detection of mRNA. He also co-chaired the PCAST report titled, “Engage to Excel,” focusing on teaching and engagement issues involving students who are in their mirkon two years of undergraduate study at R-1, 2 and 4-year institutions, and community colleges.
Leave a Reply Cancel reply Enter your comment here Post was not sent – check your email addresses! SmartFlares are a very minor part of the article.
This could be accomplished either through a pH-dependent mechanism or in response to something like glutathione which has a much higher concentration in the cytosol: The authors are from Northwestern, i. Antisense gene regulation cannot happen without the particles going out of the endosomes.
A RESPONSE FROM CHAD MIRKIN’S GROUP [follow up #1/n] | Rapha-z-lab
Inhe was listed as the most cited chemist in the world over the last decade in terms thessi total citations, the second highest most cited chemist  in terms of impact factor,  and the top most cited nanomedicine researcher. Phoenix, ArizonaU. But keep in mind that the same gene regulation effect can be seen with multivalent oligonucleotide nanoparticles of varying cores, such as self-assembled micellar structures, e.
Views Read Edit View history. Retrospective and Outlook, Boston and Berlin: ChemistryMaterials scienceand Nanotechnology. Retrieved 14 November I agree; edited accordingly.
Email Address never made public. In addition to his academic and research imrkin, Mirkin has been involved in shaping science policy decisions. Notify me of new posts via email. Polyplex, Can you summarize the mechanism by which the oligonucleotides escape the endosome and interact with intracellular RNA?
You are commenting using your Google account.
Retrieved January 31, Mirkin was born November 23,in Phoenix, Arizona. Wrighton on microelectrode devices for electrocatalysis. Beckman Young Investigators, — Rathmann professor of chemistry, professor of medicine, professor of materials science and engineeringprofessor of biomedical engineeringand professor of chemical and biological engineering, and director of the International Institute for Nanotechnology and Center for Nanofabrication and Molecular Self-Assembly at Northwestern University.
This page was last edited on 25 Marchat