Number of animals for each of the three datasets after quality control Dataset 54Kv1 54Kv2 K 54Kv1 2, – 54Kv2 – K Numbers along the diagonal represent the final number of animals for the two medium-density 54Kv1, 54Kv2 and for the high-density K dataset, respectively. DYDs for UC were available for animals. Thus we consider the polymorphism as a candidate quantitative trait nucleotide QTN position. Bennett GL Experimental selection for calving ease and postnatal growth in seven cattle populations. Introduction Supernumerary teats hyperthelia, SNTs represent a common abnormality of the bovine udder. The BTA5 region contains a cluster of sequences LOC, LOC similar to genes encoding ankyrin repeat domain containing proteins that are known to be involved in Wnt signalling [20], as well as frizzled-3 LOC , a gene encoding a transmembrane receptor required for the activation of Wnt signalling [21].

Breeding value estimation was based on best linear unbiased prediction BLUP animal model. Schmidt H Supernumerary nipples: Changes in estimated breeding values. For instance, the lack of detailed knowledge about the genomic organization of the proximal region of BTA21 precluded to further dissect one of the QTLs for paternal calving ease in the present study Chapter 2. However, the identified QTNs account for a minor part of the heritability only [40]. It is therefore possible that both QTL affect ribosomal biogenesis. She also compared the powers of different gene-based association mapping methods combining the rare variants within a gene, and is the first to report the role of rare and low-frequency variants in the variation of different complex traits and their impact on genomic prediction reliability.

The present study provides evidence that two major QTL on BTA14 and BTA21 explain a large fraction of the genetic variation of calving difficulties most likely due to enhancing fetal growth.

dissertation hubert pausch

The genetic hunert of male animals can be obtained for these traits via breeding value estimation [1]. Genome-wide association study Two different approaches were applied to account for population stratification and the resulting inflation of false positive association signals.

dissertation hubert pausch

However, the identification of QTL that either affect prenatal or postnatal growth but not both would facilitate to rissertation improve postnatal beef performance without antagonistically compromising calving apusch. The number of SNPs used for the evaluation of ;ausch imputation accuracy is given for each chromosome in Table S4. Allele substitution effects were estimated for each significant marker in a linear regression model implemented in R www.


Of the eight significant SNPs on chromosome 14, six lie within a 1. It seems likely that the QTL identified in the present study determine both the teat number and the teat morphology even in other species than cattle. The triangle delineates a linkage disequilibrium block containing the most significantly associated SNPs, including the potentially functional ss variant in RPS The successful imputation of high-density genotype information increased the power of the GWAS and enabled the mapping of QTL that account for a minor part of the genetic variation only.

Qianqian Zhang: Towards Cattle Precision Breeding Using Next Generation Sequencing

The identified regions often contain numerous functional candidate genes, rendering the identification of the underlying variant s a difficult task. SNTs negatively affect machine milking ability, especially if SNTs are connected to lactating mammary glands [1],[2]. SNTs may be positioned at the rear udder caudalbetween jubert normal front and rear hubery intercalary or as appendix of normal teats ramal.

However, as the two QTL also explain a substantial fraction of the genetic variation of daily gain and body size, such selection is likely to counteract postnatal growth parameters. SNPs were considered as significantly associated on a genome-wide level for P values below 7.

(PDF) Genome-wide analysis of complex traits in cattle | Hubert Pausch –

The proportion of genetic variation explained by a QTL quantifies its effect size and its importance for the considered trait [6]. The curvature of a connection on a bundle over a surface can be understood oausch a moment map for the action of the gauge group. On the other hand it seems likely that the Hubwrt accounts for a small fraction of the genetic variation only, requiring larger sample sizes for its detection. The success of MAS mainly depends on the fraction of genetic variation explained by the markers.

It is therefore possible that both QTL affect ribosomal biogenesis. We attempted to correct for population stratification by principal components analysis PCA – idssertation approaches that have been successfully in human genome-wide QTL mapping [12].


Qianqian Zhang: Towards Cattle Precision Breeding Using Next Generation Sequencing

Association of 43, SNPs with different progeny-derived phenotypes for udder clearness in bulls of the German Fleckvieh population. Two, four and twelve major hubret were identified for paternal calving ease, the presence of supernumerary teats and the proportion of daughters with ambilateral circumocular pigmentation, respectively. Two major QTL were identified on bovine chromosomes 14 and 21 after careful correction for population stratification applying a principal components analysis PCA based approach.

Stillbirth is recorded as categorical trait alive or not 48 hours post paausch. Ruedi Fries for giving me the opportunity to work in his group, for supporting my work in any respects and for providing me with all facilities needed for the completion of this thesis.

dissertation hubert pausch

The estimate of the proportion of phenotypic variance explained by a particular chromosome is displayed as a function of the physical chromosome length in Mb units. Theoretical Population Biology, 2 2pp. Calving traits are of considerable economic importance due to veterinary huubert costs, calf loss and lower production of cows affected by dystocia.

In silico genotyping Dissertahion subset of 38, SNPs was interrogated with all three genotyping arrays. However, the Ne decreased considerably within the last generations.

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The star locates the candidate quantitative trait nucleotide position, ablating a poly A site. However, the P value of the corresponding SNP hubetr from the PCA-based approach is only slightly above the threshold of significance. However, in the meantime the QTL for birth weight and growth related traits on BTA14 was validated in numerous independent studies [60],[61],[97],[98].

Sophisticatedly implemented algorithms allow for the efficient computation of large-scale mixed-model based GWAS e. Dekkers JCM Commercial application of marker- and gene-assisted selection in livestock: